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Syntheses of 1‐substituted 1,2,4‐triazoles, imidazoles and benzimidazoles
Author(s) -
Sharifian Abdollah,
Parang Kaykavoos,
ZorriehAmirian Hassan,
Nazarinia Mehrdad,
Shafiee Abbas
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310621
Subject(s) - chemistry , yield (engineering) , halide , hydride , sodium hydride , combinatorial chemistry , organic chemistry , medicinal chemistry , hydrogen , materials science , metallurgy
Substituted 2‐phenethyl‐1,2,4‐triazoles, 1‐phenethylimidazoles 3 and 1‐phenethylbenzimidazoles 5 were synthesized from the reaction of compound 8 with tri‐ n ‐butyltin hydride in good yield. The reaction of substituted‐2‐phenethyl halide with 1 H ‐1,2,4‐triazoles, imidazoles and benzimidazoles gave a low yield. The yield was increased by the use of substituted‐2‐phenethyl p ‐toluensulfonate.