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Metalation of diazines. XI . Directed ortho ‐lithiation of fluoropyrimidines and application to synthesis of an azacarboline
Author(s) -
Plé N.,
Turck A.,
Heynderickx A.,
Quéguiner G.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310602
Subject(s) - chemistry , metalation , electrophile , derivative (finance) , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , financial economics , economics
For the first time fluoropyrimidines were successfully lithiated. The resulting lithio derivatives were reacted with various electrophiles for the synthesis of new pyrimidines. The synthesis of an azacarboline derivative is reported.