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Synthesis of tetrahydroimidazo[1,5‐ b ]‐β‐carboline derivatives with complex basic substituents
Author(s) -
De Miguel Pilar,
Martín Nazario,
Braña Miguel F.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310521
Subject(s) - chemistry , combinatorial chemistry , stereochemistry , nitrogen , organic chemistry
Abstract Novel tetrahydroimidazo[1,5‐ b ]‐β‐carbolines derivatives 6 bearing complex basic chains as substituents on the imidic nitrogen have been prepared in a one‐pot reaction. This simple experimental procedure overcomes the direct handle of isocyanates which can be favorably generated “ in situ ” from carbonyldiimidazole (CDI) and different amines. The stereochemistry of the novel compounds was determined by nmr experiments.