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Studies on pyrrolidones. Synthesis and reactivity of β‐enaminomono‐esters and β‐enaminomononitriles derived from pyroglutamic acid
Author(s) -
Fasseur Dominique,
Cauliez Pascal,
Couturier Daniel,
Rigo Benoît,
Defretin Sebastien
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310424
Subject(s) - chemistry , pyroglutamic acid , acylation , alkylation , reactivity (psychology) , riluzole , derivative (finance) , carbamate , iodide , organic chemistry , medicinal chemistry , stereochemistry , glutamate receptor , catalysis , amino acid , biochemistry , medicine , alternative medicine , receptor , pathology , financial economics , economics
In the pyroglutamic acid series, β‐enaminoesters 3 were formed in the 2‐position by opening of the corresponding Meldrum's derivative 6 , and β‐enaminonitriles 4 were obtained by treating carbamate vinylogous 5 by trimethytsilyl iodide. Alkylation and acylation of β‐enaminoester 3a was briefly examined.