Studies on pyrrolidones. Synthesis and reactivity of β‐enaminomono‐esters and β‐enaminomononitriles derived from pyroglutamic acid | Zendy

Fasseur Dominique | Zendy; Cauliez Pascal | Zendy; Couturier Daniel | Zendy; Rigo Benoît | Zendy; Defretin Sebastien | Zendy

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Studies on pyrrolidones. Synthesis and reactivity of β‐enaminomono‐esters and β‐enaminomononitriles derived from pyroglutamic acid

Author(s) -

Fasseur Dominique,

Cauliez Pascal,

Couturier Daniel,

Rigo Benoît,

Defretin Sebastien

Publication year - 1994

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570310424

Subject(s) - chemistry , pyroglutamic acid , acylation , alkylation , reactivity (psychology) , riluzole , derivative (finance) , carbamate , iodide , organic chemistry , medicinal chemistry , stereochemistry , glutamate receptor , catalysis , amino acid , biochemistry , medicine , alternative medicine , receptor , pathology , financial economics , economics

In the pyroglutamic acid series, β‐enaminoesters 3 were formed in the 2‐position by opening of the corresponding Meldrum's derivative 6 , and β‐enaminonitriles 4 were obtained by treating carbamate vinylogous 5 by trimethytsilyl iodide. Alkylation and acylation of β‐enaminoester 3a was briefly examined.

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