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Synthesis of unsymmetrically substituted 4 H ‐1,2,4‐triazoles
Author(s) -
Carlsen Per H. J.,
Jørgensen Kåre B.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310419
Subject(s) - chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry
Abstract A general method was developed for the synthesis of unsymmetrically 3,5‐disubstituted 4 H ‐1,2,4‐tria‐zoles (Ph, H or Ph, CH 3 ) with allyl or benzyl groups in the 4‐ring position. The reaction of the corresponding 3,5‐disubstituted 1,3,4‐oxadiazoles with allylamine or benzylamine gave the desired compounds. The oxadiazoles were prepared by heating at 100° N,N' ‐diacylhydrazines with phosphorus pentoxide.