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6,6‐Disubstituted furo[3,4‐ c ]isoxazoles and 7,7‐disubstituted pyrano‐[3,4‐ c ]isoxazoles from intramolecular cycloaddition reactions
Author(s) -
Schneider Raphaël,
Gérardin Philippe,
Loubinoux Bernard
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310418
Subject(s) - chemistry , intramolecular force , cycloaddition , isoxazole , medicinal chemistry , 1,3 dipolar cycloaddition , organic chemistry , catalysis
The reaction of β‐nitroenones with unsaturated alkoxides anions, followed by intramolecular 1,3‐dipolar cycloaddition, afforded in good yields 6,6‐disubstituted furo[3,4‐ c ]isoxazoles and 7,7‐disubstituted pyrano[3,4‐ c ]isoxazoles.
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