Premium
Facile synthesis of novel spiro[azetidine‐2,4′(1′ H )‐isoquinoline‐1′,3′,4(2′ H )‐triones]
Author(s) -
Malamas Michael S.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310254
Subject(s) - chemistry , thionyl chloride , azetidine , isoquinoline , quinoline , chloride , halogenation , medicinal chemistry , organic chemistry
A convenient general method for the synthesis of a new heterocycle, spiro[azetidine‐2,4′(1′ H )‐iso‐quinoline‐1′,3′,4(2′ H )‐trione] is described. The key intermediate 2 was prepared by direct halogenation of position‐4 of acid 3 with thionyl chloride, and subsequent treatment of the generated 4‐Cl, 4‐acetyl chloride 11 with a THF/NH 3 solution at low temperature.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom