Premium
Syntheses of reactive fluorescent stains derived from 5(2)‐aryl‐2(5)‐(4‐pyridyl)oxazoles and bifunctionally reactive linkers
Author(s) -
Litak Peter T.,
Kauffman Joel M.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310236
Subject(s) - chemistry , oxazole , maleimide , isothiocyanate , fluorescence , propylamine , piperidine , aryl , sulfonate , organic chemistry , acridine derivatives , polymer chemistry , combinatorial chemistry , amine gas treating , stereochemistry , physics , alkyl , quantum mechanics , sodium
Several bifunctionally reactive linkers containing halide or sulfonate ester groups were prepared. The linkers were used to quaternize 5‐(4‐methoxyphenyl)‐2‐(4‐pyridyl)oxazole and 2‐(6‐chromanyl)‐5‐(4‐pyridyl)oxazole to produce fluorescent stains that contained a reactive group such as an isothiocyanate, an N ‐hydroxysuccinimidyl ester, a maleimide, or an oxirane. The stains were derivatized with either 1‐propylamine, 1‐propanethiol, or piperidine, as appropriate, to help in characterization. The stains may serve as more photostable alternatives to fluoresceins or coumarins.