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Enzymatic resolution of 4‐methyl‐, 4‐phenyl‐ and 6‐phenyltetrahydro‐2 H ‐pyran‐2‐one using esterases
Author(s) -
Izumi Taeko,
Tamura Futoshi,
Akutsu Mitsuyo
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310233
Subject(s) - chemistry , pyran , esterase , enantioselective synthesis , hydrolysis , optically active , resolution (logic) , enzyme , stereochemistry , enzymatic hydrolysis , organic chemistry , catalysis , artificial intelligence , computer science
Enantioselective hydrolysis of racemic tetrahydro‐2 H ‐pyran‐2‐ones (δ‐valerolactones) using esterase resulted in the formation of optically active ( R )‐4‐methyl‐, ( R )‐4‐phenyl‐ or ( R )‐6‐phenyltetrahydro‐2 H ‐pyran‐2‐ones and the corresponding ( S )‐8‐hydroxypentanoic acid derivatives.