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Synthesis of 1,4‐dihydro‐4‐oxopyrrolo[1,2‐ b ]pyridazine‐3‐carboxylic acids and 1,4‐dihydro‐4‐oxoimidazo[1,5‐ b ]pyridazine‐3‐carboxylic acids as potential antibacterial agents
Author(s) -
Ruxer J. M.,
Lachoux C.,
Ousset J. B.,
Torregrosa J. L.,
Mattioda G.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310228
Subject(s) - pyridazine , chemistry , carboxylic acid , quinolone , antibacterial activity , stereochemistry , antibiotics , organic chemistry , bacteria , biochemistry , biology , genetics
To check the antibacterial potential of two families of aza analogues of the quinolones, 1,4‐dihydro‐4‐oxopyrrolo[1,2‐ b ]pyridazine‐3‐carboxylic acids and 1,4‐dihydro‐4‐oxoimidazo[1,5‐ b ]pyridazine‐3‐carboxylic acids, we have prepared a few derivatives in theses families using N ‐aminopyrrole and N ‐aminoimidazole derivatives as starting building blocks and the classical pathways of the quinolone series. The compounds showed no interesting antibacterial activity.