Studies on isocyanides and related compounds. A convenient synthesis of 2,3‐disubstituted spiroimidazolones | Zendy

Bossio Ricardo | Zendy; Marcaccini Stefano | Zendy; Papaleo Sandro | Zendy; Pepino Roberto | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Studies on isocyanides and related compounds. A convenient synthesis of 2,3‐disubstituted spiroimidazolones

Author(s) -

Bossio Ricardo,

Marcaccini Stefano,

Papaleo Sandro,

Pepino Roberto

Publication year - 1994

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570310225

Subject(s) - chemistry , formamides , carbanion , isocyanide , butyllithium , ammonium formate , organic chemistry , condensation , ammonium , acetamide , medicinal chemistry , acetonitrile , formamide , physics , thermodynamics

The four‐component condensation between cycloketones 1 , ammonium formate, and isocyanides 2 afforded formamides 3 , which were dehydrated to the corresponding isocyanides 4 . Upon treatment with n ‐butyllithium, compounds 4 cyclized to spiroimidazolones 6 , via the carbanions 5 . A series of 2,3‐disubstituted spiroimidazolones 8 was obtained by reacting 5 with aldehydes 7 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research