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Addition of diamines to methylthiopyridones
Author(s) -
Hehemann David G.,
Winnik Witold
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310224
Subject(s) - chemistry , combinatorial chemistry , organic chemistry
Thiopyridone derivatives react with diamines: ethylenediamine, 1,3‐propylenediamine and 1,4‐butylenediamine to produce bicyclic addition compounds. Ethanolamine reacts with thiopyridone derivatives to afford only open chain adducts. Diethylenetriamine and 2‐(2‐aminoethylamino)ethanol in reaction with thiopyridones yielded seven membered ring tricyclic derivatives. The procedures described here constitute a relatively simple method to prepare these novel heterocycles.