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Intramolecular [4 + 2] cycloaddition reactions of pyridazino‐[4,5‐ d ]pyridazines with acetylenic side‐chain dienophiles: Synthesis of f ‐annelated phthalazines
Author(s) -
Haider Norbert,
Loll Claudia
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310217
Subject(s) - chemistry , cycloaddition , intramolecular force , phthalazine , thioether , medicinal chemistry , pyridazine , stereochemistry , organic chemistry , catalysis
Starting from the thione 1 , a series of 1‐(alkynyl‐X)‐4‐phenylpyridazino[4,5‐ d ]pyridazines 4–8 (X = 0, NH, S) was prepared. Thermally induced intramolecular [4+2] cycloaddition reactions of the ethers 4, 5 and the thioether 8 afforded f ‐annelated phthalazine derivatives.