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γ‐Radiolysis of 5‐fluorouracil and 5‐fluorouridine derivatives having sulfur‐containing substituents
Author(s) -
Kuroda Tokuyuki,
Hisamura Koji,
Nishikawa Hiroshi,
Nakamizo Nobuhiro,
Otsuji Yoshio
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310213
Subject(s) - chemistry , radiolysis , reactivity (psychology) , sulfonyl , sulfur , medicinal chemistry , photochemistry , organic chemistry , radical , alkyl , medicine , alternative medicine , pathology
γ‐Radiolysis reactions of eight 5‐fluorouracil (5‐FU) derivatives having sulfonyl group‐containing substituents at the 1‐position and five 5‐fluorouridine (5‐FUR) derivatives having thioureido group‐containing substituents were studied under the conditions where hydrated electron (e aq − ) and hydroxyl radical (HO·) become the principal reactive species. The 5‐FU and 5‐FUR derivatives were radiolyzed to give 5‐FU and 5‐FUR, respectively. The efficiency of the reactions depended upon the nature of reactive species and also upon the nature of substituents. The reactivity features of the γ‐radiolysis reactions are discussed.