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Reaction of enaminonitriles with isocyanates. Synthesis of new 2‐oxo‐ and 6‐oxopyrimidines
Author(s) -
Cocco Maria Teresa,
Congiu Cenzo,
Maccioni Antonio,
Onnis Valentina
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310212
Subject(s) - chemistry , adduct , aryl , substitution (logic) , organic chemistry , medicinal chemistry , alkyl , computer science , programming language
The reaction of enaminonitriles 1 with aryl or benzyl isocyanates afforded C‐ 3–5 or N‐adducts 6–8 or a mixture of both depending on the substitution pattern of the considered enaminonitrile. The one‐step synthesis of 6‐oxopyrimidines 9–11 and 2‐oxopyrimidines 12–14 by cyclization of compounds 3–5 and 6–8 respectively is also described.