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New general synthesis of tetrahydro‐1,2,4,5‐tetrazin‐3(2 H )‐one derivatives and stable 3,4‐dihydro‐3‐oxo‐1,2,4,5‐tetrazin‐1(2 H )‐yl radical derivatives
Author(s) -
Milcent René,
Barbier GÉO,
Capelle Sylvie,
Catteau JeanPierre
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310210
Subject(s) - chemistry , medicinal chemistry , computational chemistry
Reactions of 2‐chloroformylhydrazones of aromatic aldehydes or ketones 2 with various hydrazines were converted to monocarbonohydrazone derivatives 3 or 5 and/or tetrahydro‐1,2,4,5‐tetrazin‐3(2 H )‐one derivatives 6 , 7 . By oxidation with lead dioxide, compounds 6 were transformed into stable 3,4‐dihydro‐3‐oxo‐1,2,4,5‐tetrazin‐1(2 H )‐yl radical derivatives 8 .