Premium
Heterocyclizations in the pyrido[2,3‐ b ]pyrazine series
Author(s) -
Blache Y.,
Gueiffier A.,
Chavig O.,
Teulade J. C.,
Milhavet J. C.,
Viols H.,
Chapat J. P.,
Dauphin G.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310127
Subject(s) - pyrazine , chemistry , indolizine , regioselectivity , series (stratigraphy) , reactivity (psychology) , stereochemistry , group (periodic table) , medicinal chemistry , organic chemistry , medicine , paleontology , alternative medicine , pathology , biology , catalysis
In this paper, we report the results of heterocyclizations in the pyrido[2,3‐ b ]pyrazine series to give the pyrido[2,3‐ e ] or [3,2‐ e ]pyrrolo[1,2‐ a ]pyrazine. The Clauson‐Kaas reaction on 2,3‐diaminopyridine is investigated; regioselectivity on the 3‐amino group is shown by 1 H‐ and 13 C‐nmr. Synthesis and reactivity of the original pyrazino[2,3‐ g ]indolizine series is also reported.