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Synthesis of some novel fused tetracyclic quinolonecarboxylic acids via 7‐methyl‐6,7,8,9‐tetrahydro‐3 H ‐imidazo[4,5‐ f ]quinoline and 6‐methyl‐5,6,7,8‐tetrahydro‐1 H ‐imidazo[4,5‐ g ]quinoline
Author(s) -
Le Goff Corinne,
Bouyssou Pascal,
Chenault Jacques
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310126
Subject(s) - chemistry , quinoline , stereochemistry , bicyclic molecule , combinatorial chemistry , organic chemistry
A series of fused tetracyclic quinolonecarboxylic acids was prepared for biological evaluation. These compounds were synthesized by a route involving a regiospecific functionalization of 5‐fluoro‐2‐methyl‐1,2,3,4‐tetrahydroquinoline to obtain a series of new substituted 7‐methyl‐6,7,8,9‐tetrahydro‐3 H ‐imidazo[4,5‐ f ]quinolines and 6‐methyl‐5,6,7,8‐tetrahydro‐1 H ‐imidazo[4,5‐ g ]quinolines as convenient precursors of quinolones.