Synthesis of isocoumarin, 1‐isoquinolone and 4(1 H )‐quinolone derivatives  via  seleno‐intermediates | Zendy

Izumi Taeko | Zendy; Morishita Nobuya | Zendy

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Synthesis of isocoumarin, 1‐isoquinolone and 4(1 H )‐quinolone derivatives via seleno‐intermediates

Author(s) -

Izumi Taeko,

Morishita Nobuya

Publication year - 1994

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570310125

Subject(s) - isocoumarin , chemistry , isocoumarins , quinolone , coumarin , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , antibiotics , catalysis , biochemistry

The reaction of 2‐styrylbenzoic acids 2 with N ‐phenylselenosuccinimide (N‐PSS) affords 3‐phenyl‐iso‐coumarin derivatives 3 and 3,4‐dihydro‐3‐phenyl‐4‐(phenylseleno)isocoumarins 4 via selenolactonization. The reaction of 2‐styrylbenzamides 5 and 1‐(2‐aminophenyl)‐3‐phenyl‐2‐peropen‐1‐one derivatives 11 with N‐PSS also resulted in the formation of 1‐isoquinolone 6 and 4(1 H )‐quinolone derivatives 12 , respectively.

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