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Synthesis of isocoumarin, 1‐isoquinolone and 4(1 H )‐quinolone derivatives via seleno‐intermediates
Author(s) -
Izumi Taeko,
Morishita Nobuya
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310125
Subject(s) - isocoumarin , chemistry , isocoumarins , quinolone , coumarin , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , antibiotics , catalysis , biochemistry
The reaction of 2‐styrylbenzoic acids 2 with N ‐phenylselenosuccinimide (N‐PSS) affords 3‐phenyl‐iso‐coumarin derivatives 3 and 3,4‐dihydro‐3‐phenyl‐4‐(phenylseleno)isocoumarins 4 via selenolactonization. The reaction of 2‐styrylbenzamides 5 and 1‐(2‐aminophenyl)‐3‐phenyl‐2‐peropen‐1‐one derivatives 11 with N‐PSS also resulted in the formation of 1‐isoquinolone 6 and 4(1 H )‐quinolone derivatives 12 , respectively.