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The reaction of aromatic α,β‐unsaturated ketones with 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐ones
Author(s) -
Insuasty Braulio,
Ramos MÓNica,
Quiroga Jairo,
Sanchez Adolfo,
Nogueras Manuel,
Hanold Norbert,
Meier Herbert
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310111
Subject(s) - chemistry , decoupling (probability) , medicinal chemistry , organic chemistry , stereochemistry , computational chemistry , engineering , control engineering
The reaction of 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐ones 1 with one equivalent of the chalcones 2 leads in an acidic medium to the formation of the 2,4‐diaryl‐2,3,6,7‐tetrahydro‐1 H ‐pyrimido[4,5‐ b ][1,4]diazepin‐6‐ones 3a‐m . The structure elucidation of the products is based on detailed nmr investigations including selective 13 C[ 1 H] decoupling experiments.