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New quinoxalines with nitrogen functions in the side chain. Potential inhibitors of 5‐HT 3
Author(s) -
Monge A.,
Palop J. A.,
Del Castillo J. C.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310105
Subject(s) - chemistry , side chain , nitrogen , alkoxy group , nitrogen dioxide , amidine , medicinal chemistry , stereochemistry , organic chemistry , alkyl , polymer
Starting with benzofuroxane 1 , 2‐ethoxy‐carbonyl‐3‐methylquinoxaline 1,4‐dioxide 7 is obtained. From this compound different amides 5a‐q and amino esters 6a‐c are obtained. From 2‐amino‐3‐cyanoquinoxaline 1,4‐dioxide 7 , new amidines 9 , [5,4‐ b ]pyrimido 10 and [6,5‐ b ]diazepinoquinoxalines 11 were prepared.