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A synthetic route to 3‐(dialkylamino)phenothiazin‐5‐ium salts and 3,7‐disubstituted derivatives containing two different amino groups
Author(s) -
Strekowski Lucjan,
Hou DongFeng,
Wydra Roman L.,
Schinazi Raymond F.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300641
Subject(s) - chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry
Phenothiazin‐5‐ium tetraiodide hydrate ( 2 ), the suggested oxidation product of phenothiazine with iodine, is treated with two equivalents of a dialkylamine to give 3‐(dialkylamino)phenothiazin‐5‐ium triiodides, 3‐6 . 3,7‐Disubstituted phenothiazin‐5‐ium iodides, 7‐9 , are obtained by the reaction of 3‐6 with an amine.
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