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The synthesis of 6,9‐difluorobenzo[g]quinoline‐5,10‐dione. Displacements of the fluorides by diamines which lead to 6,9‐bis[(aminoalkyl)amino]benzo[g]quinoline‐5,10‐diones
Author(s) -
Krapcho A. Paul,
Petry Mary E.,
Landi John J.,
Stallman John,
Polsenberg Johanna F.,
Hacker Miles P.,
Spinelli Silvano,
Oliva Ambrogio,
Di Domenico Roberto,
Menta Emesto
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300619
Subject(s) - quinoline , chemistry , yield (engineering) , medicinal chemistry , stereochemistry , organic chemistry , metallurgy , materials science
The synthesis of 6,9‐difluorobenzo[g]quinoline‐5,10‐dione ( 3b ) is described. Facile ipso substitutions of the fluorides from 3b by diamines readily yield the corresponding 6,9‐bis[(aminoalkyl)amino]benzo‐[g]quinoline‐5,10‐diones 2 . The analogue 2d has been synthesized by side arm modifications of dione 8a .

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