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Synthesis of 1,6‐dihydro‐5‐hydroxy‐6‐oxo‐3‐(trifluoromethyl)‐4‐pyridazinecarboxylates
Author(s) -
Hegde Shridhar G.,
Jones Claude R.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300607
Subject(s) - chemistry , trifluoromethyl , ether , aryl , williamson ether synthesis , alkyl , medicinal chemistry , organic chemistry , stereochemistry
The reaction of 2‐(alkylamino)‐3‐(trifluoroacetyl)butenedioates 2a‐b with alkyl and aryl hydrazines in ether provides 1,6‐dihydro‐6‐oxo‐3‐(trifluoromethyl)‐4‐pyridazinecarboxylates as their alkylamine salts 3a‐g . The structures of these products are substantiated using 2D nmr and 15 N nmr techniques.
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