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Diazines. IX . Metalation of 2‐chloro, 2‐methoxy and 2‐pivaloylaminoquinoxaline
Author(s) -
Turck A.,
Ple N.,
Tallon V.,
Queguiner G.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300605
Subject(s) - chemistry , metalation , medicinal chemistry , iodine , organic chemistry
The lithiation of 2‐chloro, 2‐methoxy and 2‐pivaloylaminoquinoxaline was studied. In the case of 2‐chloro and 2‐methoxyquinoxaline the simultaneous formation of dimers could not be avoided. The resulting lithio derivatives were reacted with carbonyl compounds and iodine. Yields in excess of 50% were obtained.