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Synthesis of imidazo[1,2‐ b ]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives
Author(s) -
Mourad Alaa E.,
Wise Dean S.,
Townsend Leroy B.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300531
Subject(s) - chemistry , pyridazine , stereochemistry , benzimidazole , organic chemistry
A series of imidazo[1,2‐ b ]pyridazines has been prepared and evaluated for macrofilaricidal activity against Brugia pahangi or Acanthocheilonema viteae infections in jirds. The imidazo[1,2‐ b ]pyridazine analogs of fen‐bendazole and oxifenbendazole are reported. In addition, several 6‐aminoimidazo[1,2‐ b ]pyridazine derivatives have been prepared. None of these compounds possessed significant activity against human cytomega‐lovirus (HCMV) or filarial infections.