Premium
Synthesis of a new series of 8‐substituted‐2,8‐diazaspiro[4.5]decan‐3‐ones
Author(s) -
Cignarella Giorgio,
Villa Stefania,
Barlocco Daniela
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300529
Subject(s) - chemistry , in vivo , cholinergic , in vitro , muscarinic acetylcholine receptor , series (stratigraphy) , stereochemistry , combinatorial chemistry , pharmacology , biochemistry , medicine , receptor , paleontology , microbiology and biotechnology , biology
Abstract A new series of 8‐substituted‐2,8‐diazaspiro[4.5]decan‐3‐ones has been synthesized and tested in in vitro and in vivo assays predictive for cholinergic activity, in comparison with the muscarinic agent RS‐86. Preliminary pharmacological data indicate that the compounds are devoid of significant cholinergic properties.