2′‐ O ,5‐dimethyluridine: A total synthesis and single crystal X‐ray diffraction study | Zendy

Lewis Arthur F. | Zendy; Revankar Ganapathi R. | Zendy; Hogan Michael E. | Zendy

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2′‐ O ,5‐dimethyluridine: A total synthesis and single crystal X‐ray diffraction study

Author(s) -

Lewis Arthur F.,

Revankar Ganapathi R.,

Hogan Michael E.

Publication year - 1993

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570300522

Subject(s) - chemistry , yield (engineering) , moiety , nucleoside , single crystal , x ray , diffraction , stereochemistry , crystallography , optics , materials science , physics , metallurgy

A new method for the synthesis of 2′‐ O ,5‐dimethyluridine ( 5 ) has provided the title compound in a higher yield. Application of a one‐pot ribosylation methodology resulted in an efficient, high yield synthesis of 5‐methyluridine (ribothymine, 3b ). An X‐ray diffraction analysis of 5 disclosed the conformation of the sugar moiety of this nucleoside as anti , N (3′‐endo), g + .

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