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Synthesis of 1‐( N ‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones
Author(s) -
Piao MingZhu,
Wang DaoLin,
Lu DuRen,
Imafuku Kimiaki
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300512
Subject(s) - chemistry , formaldehyde , methane , condensation , medicinal chemistry , tris , organic chemistry , biochemistry , physics , thermodynamics
Reactions of 3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐one ( 2 ) with arylamines in the presence of formaldehyde gave 1‐( N ‐arylaminomethyl)‐3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones 5a‐l in good yields. 1,3,5‐Tris(phenyl‐ and 4‐methoxyphenyl)hexahydro‐1,3,5‐triazines or bis(3‐nitroanilino)methane, which were condensation products of arylamines and formaldehyde, also reacted with compound 2 to afford 5a,c,j , respectively.