Preparation of 3(5)‐phenyl‐1‐hydroxypyrazole 2‐oxide and 4‐methyl‐3(5)‐phenyl‐1‐hydroxypyrazole 2‐oxide | Zendy

Hansen John F. | Zendy; Luther Matthew L. | Zendy

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Preparation of 3(5)‐phenyl‐1‐hydroxypyrazole 2‐oxide and 4‐methyl‐3(5)‐phenyl‐1‐hydroxypyrazole 2‐oxide

Author(s) -

Hansen John F.,

Luther Matthew L.

Publication year - 1993

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570300461

Subject(s) - chemistry , oxide , medicinal chemistry , organic chemistry

Nitrosation of acrylophenone oxime or of methacrylophenone oxime with n ‐butyl nitrite in the presence of pyridine and copper(II) sulfate gives the copper complexes of the title compounds. The free 1‐hydroxypyrazole 2 ‐oxides are isolated by treating the copper complexes with dilute sodium hydroxide, filtration, and acidification of the basic filtrates. The title compounds are the first examples of 1‐hydroxypyrazole 2 ‐oxides in which the C3(5) ring position is unsubstituted.

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