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Synthesis of 8‐dipropylamino‐7,8,9,10‐tetrahydrophenanthridines as potential serotoninergic agonists
Author(s) -
Castan Florence,
Bigg Dennis C. H.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300451
Subject(s) - chemistry , serotonergic , stereochemistry , combinatorial chemistry , pharmacology , serotonin , biochemistry , receptor , medicine
A number of 8‐dipropylamino‐7,8,9,10‐tetrahydrophenanthridines have been prepared as analogs of the known serotoninergic agonist 8‐hydroxy‐2‐(dipropylamino)tetralin (8‐OH‐DPAT) and their affinity for the 5‐HT 1A receptor subtype evaluated by radioligand binding assay.