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N ‐Alkylation of pyrazolones with OH‐protection
Author(s) -
Hichour M.,
Mary F.,
Marzin C.,
Naji M.,
Tarrago G.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300445
Subject(s) - chemistry , pyrazolones , pyrazolone , alkylation , bifunctional , nitrogen atom , organic chemistry , combinatorial chemistry , catalysis , ring (chemistry)
The synthesis of a biheterocyclic compound containing two pyrazolone sub‐units, precursor of a new macrocyclic family, is described. It is shown that it is necessary to protect first the pyrazol‐5‐one oxygen site before condensing it with a bifunctional compound in order to obtain a selective alkylation on the heterocyclic nitrogen atom.