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Synthesis of new 4‐quinolone‐type compounds in the benzo[ b ]thiophene series
Author(s) -
Février B.,
Dupas G.,
Bourguig J.,
Quéguiner G.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300442
Subject(s) - chemistry , thiophene , pyridine , quinolone , ring (chemistry) , amine gas treating , stereochemistry , series (stratigraphy) , combinatorial chemistry , medicinal chemistry , organic chemistry , antibiotics , biochemistry , paleontology , biology
Some new derivatives of 1,4‐dihydro‐4‐oxo‐3‐pyridinecarboxylic acid (quinolone‐type compounds) 5 and 13 have been prepared in the benzo[ b ]thiophene series. The key step was the construction of the pyridine ring starting from 2‐aminobenzo[ b ]thiophene derivatives. The synthesis of amine 9 , was performed by using an original “animation” reaction.