Premium
Ring chain transformations. XIV . 3‐(ω‐Aminoalkyl)‐1,2,4‐triazoles by reaction of isothiosemicarbazides with lactam acetals or lactim ethers
Author(s) -
Radics Ute,
Liebscher Jürgen
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300438
Subject(s) - chemistry , lactam , alkylation , ring (chemistry) , condensation , stereochemistry , organic chemistry , catalysis , physics , thermodynamics
Isothiosemicarbazide hydrohalides 1 react with lactam acetals 2 or lactim ethers 3 by the formation of lactamisothiosemicarbazones 4 or ring transformed 3‐(ω‐aminoalkyl)‐1,2,4‐triazoles 6 . The latter can independently by synthesized by alkylation of lactamthiosemicarbazones 9 . Condensation of primary 3‐(ω‐aminoalkyl)‐1,2,4‐triazoles 6 with lactim ethers 7 can lead to 3‐lactamiminoalkyl‐1,2,4‐triazoles 8 .