Ring chain transformations.  XIV  . 3‐(ω‐Aminoalkyl)‐1,2,4‐triazoles by reaction of isothiosemicarbazides with lactam acetals or lactim ethers | Zendy

Radics Ute | Zendy; Liebscher Jürgen | Zendy

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Ring chain transformations. XIV . 3‐(ω‐Aminoalkyl)‐1,2,4‐triazoles by reaction of isothiosemicarbazides with lactam acetals or lactim ethers

Author(s) -

Radics Ute,

Liebscher Jürgen

Publication year - 1993

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570300438

Subject(s) - chemistry , lactam , alkylation , ring (chemistry) , condensation , stereochemistry , organic chemistry , catalysis , physics , thermodynamics

Isothiosemicarbazide hydrohalides 1 react with lactam acetals 2 or lactim ethers 3 by the formation of lactamisothiosemicarbazones 4 or ring transformed 3‐(ω‐aminoalkyl)‐1,2,4‐triazoles 6 . The latter can independently by synthesized by alkylation of lactamthiosemicarbazones 9 . Condensation of primary 3‐(ω‐aminoalkyl)‐1,2,4‐triazoles 6 with lactim ethers 7 can lead to 3‐lactamiminoalkyl‐1,2,4‐triazoles 8 .

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