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Polycyclic N ‐heterocyclic compounds. XLV. Synthesis of 4‐substituted 5,6‐dihydrobenzo[ h ]quinazolines and 6,7‐dihydro‐5 H ‐benzo[6,7]cyclohepta[1,2‐ d ]pyrimidines and their inhibitory activity on platelet aggregation
Author(s) -
Sasaki Kenji,
Sekiya Yuhki,
Fujiwara Hideko,
Ohtomo Hiromi,
Nakayama Taiji,
Hirota Takashi
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300426
Subject(s) - chemistry , amide , stereochemistry , nitrite , medicinal chemistry , platelet aggregation , organic chemistry , platelet , nitrate , immunology , biology
The synthesis of 4‐substituted 5,6‐dihydrobenzo[ h ]quinazolines and 6,7‐dihydro‐5 H ‐benzo[6,7]cyclohepta‐[1,2‐ d ]pyrimidines with substituents which are an electron‐attracting group such as a nitrite, an amide, a thione, or a carboxyl group is described. Their inhibitory activity against collagen‐induced platelet aggregation was also investigated.