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Methylation of 5‐Phenyl‐1,4‐benzodiazepin‐2‐one derivatives with N,N ‐dimethylformamide‐dimethyl acetal
Author(s) -
Pinto Julia C.,
Fryer R. Ian
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300416
Subject(s) - chemistry , reagent , amide , acetal , ring (chemistry) , nitrogen atom , dimethyl sulfate , methylation , solvent , alkyl , medicinal chemistry , formamide , dimethyl formamide , dimethylformamide , halide , organic chemistry , combinatorial chemistry , gene , biochemistry
A novel method for N ‐methylation of the cyclic amide in the 1,4‐benzodiazepine ring system is presented. Methods traditionally used involve treatment of the 1,4‐benzodiazepinone anion with an alkyl halide. It has been demonstrated that these derivatives can be methylated on the amide nitrogen atom by use of dimethyl‐formamide dimethyl acetal which acts as both reagent and solvent for the reaction.