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Studies on pyrrolidinones. Synthesis of 2‐(5‐oxo‐2‐pyrrolidinyl)‐1,3,4‐oxadiazoles and 2‐(5‐oxo‐2‐pyrrolidinyl)benzimidazoles
Author(s) -
Cauliez Pascal,
Couturier Daniel,
Rigo Benoît,
Fasseur Dominique,
Halama Patrice
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300414
Subject(s) - chemistry , pyrrolidinones , pyroglutamic acid , antifungal , condensation , stereochemistry , combinatorial chemistry , organic chemistry , amino acid , biochemistry , medicine , physics , dermatology , thermodynamics
Abstract The condensation of pyroglutamic acids with 1,2‐phenylenediamine leads to 2‐(5‐oxo‐2‐pyrrolidinyl)benzimidazoles and the cyclization of disilylated diacylhydrazines derived from the same acids gives 2‐(5‐oxo‐2‐pyrrolidinyl)‐1,3,4‐oxadiazoles. These compounds show weak antifungal activity.