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Reissert compound studies LXVI . Regioselective synthesis of pyridine reissert analogs
Author(s) -
Duarte F. F.,
Popp F. D.,
Holder A. J.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300408
Subject(s) - chemistry , regioselectivity , pyridine , cyanide , iodide , ethyl chloroformate , medicinal chemistry , chloroformate , stereochemistry , organic chemistry , catalysis
The reaction of ethyl chloroformate and pyridine with diethylaluminum cyanide as the cyanide source gave the Reissert analog, 1‐ethoxycarbonyl‐4‐cyano‐1,4‐dihydropyridine and not the expected 1,2‐dihydro regio isomer. Under the same conditions, 3‐bromopyridine also directly gave the corresponding 1,4‐dihydro Reissert analog. Reinvestigation of trimethylsilylcyanide, as the cyanide source, resulted in the observation that both regio isomers are formed and the ratio of these isomers are affected by both solvent polarity and by copper(I) iodide.