Synthesis of cyclopentathiophenacetic acid derivatives. Reactivity of methyl 6‐oxo‐4,5‐dihydro‐6 H ‐cyclopenta[ b ]thiophen‐4‐acetate | Zendy

Jilale Abderrahim | Zendy; Netchitaïlo Pierre | Zendy; Decroix Bernard | Zendy; Vegh Daniel | Zendy

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Synthesis of cyclopentathiophenacetic acid derivatives. Reactivity of methyl 6‐oxo‐4,5‐dihydro‐6 H ‐cyclopenta[ b ]thiophen‐4‐acetate

Author(s) -

Jilale Abderrahim,

Netchitaïlo Pierre,

Decroix Bernard,

Vegh Daniel

Publication year - 1993

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570300406

Subject(s) - chemistry , reactivity (psychology) , beckmann rearrangement , bicyclic molecule , medicinal chemistry , organic chemistry , stereochemistry , oxime , medicine , alternative medicine , pathology

Oxodihydrocyclopentathiophenacetic acids 4 , 5 and 6 were synthesized from suitable 2‐ or 3‐formylthiophenes. Reactivity of the carbonyl group or the carboxylic group of these bicyclic systems was investigated. The Beckmann rearrangement of methyl 6‐oximino4,5‐dihydro‐6 H ‐cyclopenta[ b ]thiophen‐4‐acetate 12 is an interesting route to methyl 7‐oxo‐4,5,6,7‐tetrahydrothieno[2,3‐ c ]pyridin‐4‐acetate ( 13 ).

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