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An evaluation of hofmann and cope elimination routes to (±)‐2‐ n ‐propylthietane
Author(s) -
Woolhouse A. D.,
Gainsford G. J.,
Crump D. R.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300405
Subject(s) - chemistry , elimination reaction , combinatorial chemistry , oxide , organic chemistry , medicinal chemistry
Abstract A synthetic route to (±)‐2‐ n ‐propylthietane 1 that utilises a silver oxide‐induced Hofmann elimination is described together with an evaluation of the potential of a Cope elimination as an alternative and more cost‐effective route to 1 . Some chemistry of the isomeric intermediate thiete sulfones 5 and 12 from each of these respective eliminations is presented.