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Identification of a 4 H ‐benz[ f ]indole by‐product from the friedel‐crafts‐based synthesis of benzoylpyrrole calcium channel activators
Author(s) -
Huber Edward W.,
Barbuch Robert J.,
Dalton Christopher R.,
Kane John M.,
Velayo Nelson L.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300305
Subject(s) - chemistry , heteronuclear molecule , friedel–crafts reaction , indole test , calcium channel , stereochemistry , organic chemistry , calcium , combinatorial chemistry , nuclear magnetic resonance spectroscopy , catalysis
9,9a‐Dihydro‐2,9a‐dimethyl‐4‐oxo‐4 H ‐benz[ f ]indole‐3‐carboxylic acid, methyl ester was formed in varying amounts from the Friedel‐Crafts‐based synthesis of benzoylpyrrole calcium channel activators. The structure of this by‐product was determined using two‐dimensional long‐range 1 H‐ 13 C heteronuclear correlated and INADEQUATE nmr techniques.