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Facile synthesis of 5,6,7,8‐tetrahydropyrido[2,1‐ b ]purin‐10‐one
Author(s) -
Kuroda Takeshi,
Suzuki Fumio
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300302
Subject(s) - chemistry , methylation , combinatorial chemistry , product (mathematics) , stereochemistry , biochemistry , geometry , mathematics , gene
A convenient synthesis of a new heterocycle, 5,6,7,8‐tetrahydropyrido[2,1‐ b ]purin‐10‐one 1 was described. 4‐Amino‐ N ‐(5‐chloropentanoyl)‐5‐imidazolecarboxamide 3a was successively cyclized to 1 with polyphosphoric acid at 150°. Methylation of 1 under basic condition proceeded selectively at N ‐1 to afford 6 as the sole product.