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On the orientation in lithiation and bromination of dithieno[3,4‐ b :3′,2′‐ d ]pyridine
Author(s) -
Gronowitz Salo,
Hörnfeldt AnnaBritta,
Temciuc Ecaterina
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300244
Subject(s) - chemistry , halogenation , pyridine , halogen , lithium (medication) , dimethylformamide , medicinal chemistry , organic chemistry , metal , polymer chemistry , medicine , alkyl , solvent , endocrinology
The 3‐position of dithieno[3,4‐ b :3′,2′‐ d ]pyridine was found to be most reactive with regard to lithiation, bromination and halogen‐metal exchange. The lithium compounds were trapped as the formyl derivatives by reaction with N,N ‐dimethylformamide.