Premium
Stereoselective synthesis of cis and trans 2‐substituted 1‐phenyl‐3‐azabicyclo[3.1.0]hexanes
Author(s) -
Bonnaud Bernard,
Bigg Dennis C. H.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300239
Subject(s) - chemistry , stereoselectivity , stereochemistry , organic chemistry , medicinal chemistry , catalysis
The Stereoselective synthesis of cis and trans 2‐methyl‐1‐phenyl‐3‐azabicyclo[3.1.0]hexanes and 1,2‐diphen‐yl‐3‐azabicyclo[3.1.0]hexanes from 2‐oxo‐1‐phenyl‐3‐azabicyclo[3.1.0]hexane is described. The relative stereochemistry of the products was established by nuclear magnetic resonance and molecular modeling studies.