Anticancer anthrapyrazoles. The synthesis of 2‐substituted 5‐nitro and 5‐aminoanthra[1,9‐ cd ]pyrazol‐6(2 H )‐ones | Zendy

Hollis Showalter H. D. | Zendy; Turner William R. | Zendy

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Anticancer anthrapyrazoles. The synthesis of 2‐substituted 5‐nitro and 5‐aminoanthra[1,9‐ cd ]pyrazol‐6(2 H )‐ones

Author(s) -

Hollis Showalter H. D.,

Turner William R.

Publication year - 1993

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570300236

Subject(s) - chemistry , nitro , in vivo , in vitro , leukemia , stereochemistry , nitro compound , ring (chemistry) , substitution (logic) , combinatorial chemistry , biochemistry , organic chemistry , medicine , alkyl , microbiology and biotechnology , computer science , biology , programming language

Synthetic methodologies for the preparation of substituted 5‐nitro‐ and 5‐aminoanthra[1,9‐ cd ]‐pyrazol‐6(2 H )‐ones, 4 and 5 respectively, substituted with a basic side at N‐2 and dioxy substitution in the A‐ring, are reported. These compounds are essentially devoid of activity against in vitro L1210 leukemia and in vivo murine P388 leukemia.

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