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Synthesis of 3‐substituted 5‐arylisoxazoles from α,β‐unsaturated oximes
Author(s) -
Alberola Angel,
Manuel Bañez J.,
Calvo Luis,
Rodríguez Rodríguez M. Teresa,
Carmen Sañudo M.
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300231
Subject(s) - chemistry , isoxazole , iodine , iodide , potassium , organic chemistry , medicinal chemistry
The synthesis of 3‐substituted 5‐arylisoxazoles from oximes of α,β‐unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline is detected. On the basis of the results a plausible mechanism is suggested.