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Synthesis of 5‐aroylamino‐3 H ‐1,3,4‐thiadiazole‐2‐thiones and their tautomerism
Author(s) -
Cho Nam Sook,
Kim Goo Ni,
Párkányi Cyril
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300219
Subject(s) - tautomer , chemistry , acylation , stereochemistry , medicinal chemistry , thiol , organic chemistry , catalysis
5‐Aroylamino‐3 H ‐1,3,4‐thiadiazole‐2‐thiones 2 have been synthesized by acylation of 5‐amino‐3 H ‐1,3,4‐thiadiazole‐2‐thione 1 . 5‐Aroylamino‐3 H ‐1,3,4‐thiadiazole‐2‐thiones can exist in two tautomeric forms — a thiol form and a thione form. On the basis of the 13 C nmr spectra and additional experimental information, it has been established that the thione form is the stable form in which these compounds exist.