A short and general synthesis of 1,3‐dihydro‐6‐heteroaryl‐5‐perfluoroalkyl‐2 H ‐imidazo[4,5‐ b ]pyridin‐2‐ones | Zendy

Kuo GeeHong | Zendy; Bacon Edward R. | Zendy; Singh Baldev | Zendy; Eissenstat Michael A. | Zendy; Lesher George Y. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A short and general synthesis of 1,3‐dihydro‐6‐heteroaryl‐5‐perfluoroalkyl‐2 H ‐imidazo[4,5‐ b ]pyridin‐2‐ones

Author(s) -

Kuo GeeHong,

Bacon Edward R.,

Singh Baldev,

Eissenstat Michael A.,

Lesher George Y.

Publication year - 1993

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570300107

Subject(s) - chemistry , hydrolysis , medicinal chemistry , stereochemistry , azide , organic chemistry

Trifluoro or pentafluoroacylation of heteroaryl‐enamines 2a,b gave the corresponding perfluoroacylated heteroaryl‐enamines 3a‐c . Heating the latter compounds with diethyl iminomalonate gave 2‐amino‐3‐pyridinecarboxylates 4a‐c . Hydrolysis to the free acids 5a‐c , and reaction with diphenylphosphoryl azide afforded the desired 1,3‐dihydro‐6‐heteroaryl‐5‐perfluoroalkyl‐2 H ‐imidazo[4,5‐ b ]pyridin‐2‐ones 6a‐c .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research