Premium
Ring‐cleavage of isoxazoles with heterocyclic amines. Synthesis of fused pyrimidines
Author(s) -
Bossio Ricardo,
Marcaccini Stefano,
Pepino Roberto,
Paoli Paola
Publication year - 1993
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570300106
Subject(s) - chemistry , cleavage (geology) , ring (chemistry) , amidine , stereochemistry , organic chemistry , combinatorial chemistry , geotechnical engineering , fracture (geology) , engineering
The reaction between 2‐substituted ethyl 2,5‐dihydro‐5‐oxoisoxazole‐4‐carboxylates ( 2a,b ) and heterocyclic amines 1, 4 , and 6 , having the amino group in position 2 with respect to the nuclear nitrogen afforded fused pyrimidines 3, 5 , and 7 .