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Syntheses of substituted‐1,2,4‐triazoles
Author(s) -
Shafiee A.,
Naghashian F.,
Reghabi N.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290733
Subject(s) - chemistry , diazomethane , chloride , triazole , 1,2,4 triazole , organic chemistry , medicinal chemistry , combinatorial chemistry
Abstract Starting from the readily available 3‐phenylpropionitrile, 3‐(or 5‐)(2‐phenethyl)‐1,2,4‐triazole 3 was prepared. Reaction of compounds 3 with diazomethane afforded 1‐methyl‐3‐(2‐phenethyl)‐1,2,4‐triazole (4) and 1‐methyl‐5‐(2‐phenethyl)‐1,2,4‐triazole (5) . Reaction of compound 3 with methanesulfonyl chloride, benzenesulfonyl chloride or p ‐toluenesulfonyl chloride afforded only one of the expected isomer; namely compounds 6 , 7 and 8 respectively.