Syntheses of substituted‐1,2,4‐triazoles | Zendy

Shafiee A. | Zendy; Naghashian F. | Zendy; Reghabi N. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Syntheses of substituted‐1,2,4‐triazoles

Author(s) -

Shafiee A.,

Naghashian F.,

Reghabi N.

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290733

Subject(s) - chemistry , diazomethane , chloride , triazole , 1,2,4 triazole , organic chemistry , medicinal chemistry , combinatorial chemistry

Starting from the readily available 3‐phenylpropionitrile, 3‐(or 5‐)(2‐phenethyl)‐1,2,4‐triazole 3 was prepared. Reaction of compounds 3 with diazomethane afforded 1‐methyl‐3‐(2‐phenethyl)‐1,2,4‐triazole (4) and 1‐methyl‐5‐(2‐phenethyl)‐1,2,4‐triazole (5) . Reaction of compound 3 with methanesulfonyl chloride, benzenesulfonyl chloride or p ‐toluenesulfonyl chloride afforded only one of the expected isomer; namely compounds 6 , 7 and 8 respectively.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research